A recent study by an international research team has unveiled an exciting discovery about how our cells defend themselves during stressful situations. The research, published in EMBO Reports, shows that a tiny modification in the genetic material, called ac4C, acts as a crucial defender, helping cells create protective storage units known as stress granules. These stress granules safeguard important genetic instructions when the cell is facing challenges. The new findings could help shed light on relevant molecular pathways that could be targeted in disease.