Grape white rot, caused by Coniella diplodiella (Speg.) Sacc. (Cd), significantly impacts grape production and quality, highlighting the need for effective disease management strategies beyond fungicide use due to concerns over food safety and environmental impact. WRKY transcription factors are pivotal in plant pathogen resistance, yet their roles in combating grape white rot are poorly understood. This knowledge gap highlights the need for research into how WRKY transcription factors can enhance grape resistance to white rot, offering a pathway to more sustainable disease control methods.