Stable isotope analysis is an important interdisciplinary tool used by numerous fields such as nuclear and homeland security, forensics, medicine and pharmaceuticals, human health and nutrition, and climate science. Achieving reliable metrology and traceability in isotope analysis is critical as improved isotope measurements allows for advances leading to, for instance, faster conclusive analysis of forensic evidence and confidence in legal proceedings; more rigorous drug, food, and flavor authentication and identification of counterfeits; and improved understanding of mass flux in natural systems to more rigorously guide models used for remediation/mitigation and policy‑making for improved health.