Aquatic animals have historically constituted a vital and nutritious dietary component for humans, contributing to nearly 20% of animal protein intake for approximately 3.3 billion people. Unlike terrestrial animals, there has been no evidence indicating that aquatic animals serve as reservoirs for zoonotic viruses. However, multiple cases of SARS-CoV-2 from cold-chain aquatic food and environmental samples have evoked worldwide concerns, despite the incidence being notably lower than that associated with poultry and livestock.