Nobody likes needles, but they're necessary for delivering many vaccines and biologics into the body. But what if those could be puffed through the skin instead, with just a little pressure, like being hit in the arm with a foam toy? Today, scientists report steps toward making that a reality. Using powdered vaccines that don't require refrigeration and a system driven by compressed gas, their "MOF-Jet" could easily deliver therapeutics against cancer and other diseases in a relatively painless way.