Neutrophils induce anti-inflammatory -- or M2 -- macrophages deep in their granulocyte core. The dense globular structures of granulomas in animals, particularly in the lungs, have been studied. Microbes and cancer cells may manipulate this permissive microenvironment to favor their survival. A lung granuloma model in guinea pigs demonstrates the specific accumulation of Neutrophil S100A9 deep in the cores of granulomas.