During embryonic development, two different cascades of genetic signals determine whether the embryo's primordial gonad will become testes or ovaries, and thus whether the embryo will develop into a male or a female. Disruptions in this process cause disorders in sexual development characterized by a mismatch between sex-determining chromosomes, gonads (ovaries or testicles) and the anatomy of the genitals. The incompatibility can be expressed in many and varied forms, such as unclear genitalia or a combination of male and female physiological characteristics. This medical condition is termed Disorders of Sex Development (DSD) with a prevalence of 1 in 4,500 newborns.