Necroptosis is a form of regulated cell death (RCD) similar to apoptosis, the most commonly studied type of RCD. In contrast to apoptosis, plasma membrane rupture in necroptotic cells occurs at early time points. For this reason, scientists think that necroptosis elicits strong inflammation in surrounding tissues and plays a role in inflammation-associated diseases. However, it is not well understood where and when necroptosis occurs in physiological and pathological conditions in vivo.