Cilia are small hair-like organelles that extend from cells and perform many functions, including motility and signaling. Researchers have now revealed that cilia have a specialized transport hub at their base, where trains and cargos are assembled for transport throughout the cilia. Since defects in this cilia transport system can lead to conditions such as cystic kidneys or blindness, the results published in Science also provide new insights into the molecular basis for a variety of diseases.