Chemists' long-held dream of observing the structural dynamics of a single molecule have been now been made possible. Single molecules sized about 1 nanometer exist in a volatile state under ambient conditions. Considering that the coronavirus, which is about 100 nm in size, spreads rapidly in the air shows how difficult it is to observe a single molecule. Recently, a Korean research team has discovered a reliable way to observe single molecules at room temperature by capping them with a thin insulating layer, like a blanket.