Researchers from the Skoltech Center for Molecular and Cellular Biology compared different protein structure prediction methods in terms of mutant protein stability evaluation and obtained the same result for the AI-predicted structures and experimental three-dimensional (3D) of proteins with similar amino acid sequences. However, the attempt to predict the targeted protein's structure from the known structure of its "relative" only made the prediction less accurate. The team's findings will facilitate preliminary calculations in the evaluation of stability changes caused by mutation. The research was published in Bioinformatics.