Per- and polyfluoroalkyl substances (PFAS) are man-made hazardous chemicals that are spread globally in the atmosphere and as a result they can be found in the rainwater and snow in even the most remote locations on Earth. During the last 20 years, guideline values for PFAS in drinking water, surface waters and soils have decreased dramatically due to new insights into their toxicity. As a result, the levels in environmental media are now ubiquitously above guideline levels. A perspective article by researchers from Stockholm University and ETH Zurich published in Environmental Science & Technology suggests that PFAS define a new planetary boundary for novel entities that has been exceeded.