Early detection of prostate cancer, one of the most common types of cancer in men, is often achieved with PSA tests. However, this blood test for prostate-specific antigens gives many false positive results, causing unnecessary biopsies and overtreatment. In the journal Angewandte Chemie International Edition, a Chinese research team now introduces a highly specific, non-invasive alternative to biopsy: the "thermophoretic AND gate operation" assay, abbreviated as Tango, quickly and reliably detects prostate cancer directly in blood samples.