With the discovery of synthetic stem cells, better known as induced pluripotent stem cells, the field or regenerative medicine has been revolutionized. These synthetic stem cells are created by reprogramming adult cells from patients, such as human skin cells, blood cells, or urine cells, toward a pluripotent state—a cell that can become any type of cell in the human body. When forced to be one type of cells, these cells can become tiny versions of organs known as organoids. For his Ph.D. research, Johnick van Sprang developed an artificial nano-environment using next-generation materials based on supramolecular interactions, to control and refine organoid maturation through biomechanical cues.