Cells have certain proteins that help them adhere to each other while covering body surfaces and organs. Loss of these identifying proteins could result in cellular progression towards cancer and, subsequently, metastasis. However, lipids may play a role in maintaining cellular identity as well. Japanese scientists have now identified the role of PIP2, a phospholipid, in maintaining epithelial cell-cell adhesion and cellular identity. Their findings will help develop strategies aimed at suppressing metastasis.