Theoretical perspective on C-H/O-H activation by Cu-O in biological and synthetic systems
Dioxygen activations constitute one of the core issues in copper-dependent metalloenzymes. Upon O2 activation, copper-dependent metalloenzymes, including particulate methane monooxygenases (pMMOs), lytic polysaccharide monooxygenases (LPMOs) and binuclear copper enzymes PHM and DBM, are able to perform challenging C-H/O-H bond activations.
