Breathing, seeing, hearing—the family of G protein-coupled receptors (GPCRs) is involved in a variety of physiological processes and is also the cause of diverse diseases. As has now been discovered by a team of scientists led by Professor Ines Liebscher from Leipzig University, some members of the GPCR family respond to mechanical stimuli. In collaboration with Chinese research groups, they have achieved another milestone on the way to understanding the mechanism by which this receptor class is activated. For the first time, they were able to describe the structure of specific active receptors. Their findings have now been published in the journal Nature.