When plants are under drought stress, a large amount of the stress hormone abscisic acid (ABA) is produced to help them resist drought stress. In recent years, studies have found that ubiquitination mediated protein degradation plays an important role in regulating the ABA signaling pathway. Vacuolar protein sorting 23A (VPS23A), a key component of the endosomal sorting complex required for transport I, mediates the entry of ubiquitinated ABA receptors into the vacuole for degradation. The E3 ubiquitin ligase XBAT35.2 can ubiquitinate and modify VPS23A to promote its entry into the 26S proteasome for degradation, thereby positively regulating the ABA signaling pathway.