Researchers led by Prof. Xu Zhiheng from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, in collaboration with Prof. Zhang Xiaohui's Lab at Beijing Normal University, have revealed the important roles of the scaffold protein plenty of SH3s (POSH) in regulating the assembly of the NMDAR/PSD-95/Shank complex at the postsynaptic density. Results were published in Cell Reports on April 5.