Soft and immobile, sea sponges may appear inert, but these simple animals are rich with chemistry. From them, scientists have uncovered plenty of biologically active compounds, some of which have gone on to become medications. All of these small molecules, however, actually originate from bacteria living within these animals. Now, new research has uncovered an exception. Today, scientists report that sponges themselves, not their resident microbes, produce at least one promising group of compounds.