RNA-binding proteins perform multiple functions in cells, but how their pleiotropic functions are determined remains largely unknown. A research team led by Professor Kunihiro Tsuchida from Fujita Health University, Japan has discovered the pleiotropic role of heterogeneous nuclear ribonucleoprotein K (hnRNPK) in skeletal muscle cell differentiation that is both lncRNA Myoparr-dependent and -independent. Findings suggest that targeting hnRNPK to regulate multiple genes involved in disease pathologies could be a new therapeutic strategy for neuromuscular diseases.