Scientists have identified natural nano-bubbles containing the ACE2 protein (evACE2) in the blood of COVID-19 patients and discovered these nano-sized particles can block infection from broad strains of SARS-CoV-2 virus. The protein acts as a decoy in the body and can serve as a therapeutic to be developed for prevention and treatment for current and future strains of SARS-CoV-2 and future coronaviruses. It could be delivered as a nasal spray.