There are more than 9,000 species of marine sponges (Phylum Porifera) worldwide, which are a source of novel natural products. They contain promising chemical agents that may be useful in combatting cancer, COVID-19 and antibiotic-resistant Staphylococcus bacteria. These chemicals interact with molecules that have been conserved throughout evolutionary history and are involved in human disease processes, for example, cell cycling, immune and inflammatory responses, and calcium and sodium regulation.