Sen. Bill Cassidy (R-La.) joins CNBC's 'Squawk Box' to discuss Congress' efforts to overturn President Joe Biden's nationwide coronavirus vaccine mandate on businesses. Sign up and learn more about the CNBC Investing Club with Jim Cramer https://cnb.cx/3Ei22n4 The Senate voted Wednesday to block President Joe Biden’s vaccine mandate on private employers in the latest blow to his push to flex federal power to boost vaccinations in the U.S. The measure to block the mandate heads to the Democratic-held House. It faces a tougher path to passage in the House, and the Biden administration has threatened a veto if it reaches the president’s desk. Because the mandate itself has a slim chance of becoming law, the measure to overturn it will have little practical effect. A federal court has already halted the administration’s Covid vaccination and testing requirements for private businesses with 100 or more employees. Even so, the vote underscores resistance to the Biden policy even among Democrats who represent red states. It reflects the White House’s struggle to increase U.S. vaccinations and booster shots as the highly mutated omicron variant — which has shown the potential to evade protection offered by a two-dose vaccine regimen — starts to gain a foothold around the country. The Senate approved the measure in a 52-48 vote. Sens. Joe Manchin, D-W.V., and Jon Tester, D-Mont., joined every Republican in supporting it. It needed only a simple majority to pass under the Congressional Review Act, a process that allows Congress to overturn rules made by federal agencies. Republicans who introduced the plan to overturn the mandate argued it would damage small businesses as they try to navigate the pandemic. “That is the heavy hand of government, that is overreach,” Sen. Mike Braun, R-Ind., said on Wednesday. Senate Majority Leader Chuck Schumer denounced the plan on Wednesday. He said blocking the mandate would damage U.S. efforts to contain the pandemic as a potentially more infectious variant gains hold. “The worst thing we can do is to tie our own hands behind our backs, and let these new variants spread and grow and new ones after omicron and so many others. But that is what Republican-pushed, anti-vaccines would do,” he said. The vast majority of Democrats in the House will oppose the measure and it may not see a vote. Even so, if it came to a vote only four House Democrats would need to defect for it to get through both chambers. » Subscribe to CNBC TV: https://cnb.cx/SubscribeCNBCtelevision » Subscribe to CNBC: https://cnb.cx/SubscribeCNBC Turn to CNBC TV for the latest stock market news and analysis. From market futures to live price updates CNBC is the leader in business news worldwide. The News with Shepard Smith is CNBC’s daily news podcast providing deep, non-partisan coverage and perspective on the day’s most important stories. Available to listen by 8:30pm ET / 5:30pm PT daily beginning September 30: https://www.cnbc.com/2020/09/29/the-news-with-shepard-smith-podcast.html?__source=youtube%7Cshepsmith%7Cpodcast    Connect with CNBC News Online Get the latest news: http://www.cnbc.com/ Follow CNBC on LinkedIn: https://cnb.cx/LinkedInCNBC Follow CNBC News on Facebook: https://cnb.cx/LikeCNBC Follow CNBC News on Twitter: https://cnb.cx/FollowCNBC Follow CNBC News on Instagram: https://cnb.cx/InstagramCNBC https://www.cnbc.com/select/best-credit-cards/  #CNBC #CNBCTV