Researchers at Ruhr-Universität Bochum (RUB) have studied how different drugs affect the difficult-to-treat bacterium Pseudomonas aeruginosa. According to the World Health Organisation, new treatment options for the pathogen are urgently required, as some strains are already resistant to all currently approved antibiotics. The Bochum-based team headed by Professor Julia Bandow exposed P. aeruginosa to various substances and observed their effects on the protein make-up of the bacteria, also known as the proteome. The results enable the researchers to conclude what makes P. aeruginosa resistant; in addition, new approaches for treatment of the priority pathogen were investigated. Together with the group of Professor Pei Zhou from Duke University in the USA, the RUB team describes the analyses in Antimicrobial Agents and Chemotherapy.