A team of researchers at the University of Groningen has developed a multicomponent nanopore machine that approaches single molecule protein sequencing—it uses a design that allows for unfolding, threading and degrading a desired protein. In their paper published in the journal Nature Chemistry, the group describes their nanopore machine, how it works and how close it comes to allowing single molecule protein sequencing. Yi-Lun Ying with Nanjing University has published a News & Views piece in the same journal issue outlining the purpose of macromolecular machines and the work done by the team with this new effort.