Public health is coming under increasing pressure worldwide due to the antibiotic crisis: the rapid increase in resistance of bacterial pathogens could mean that in the near future bacterial infections that are usually harmless will be difficult or impossible to treat. The spread of antibiotic resistance is based on the ability of pathogens to adapt quickly to the drugs. In principle, evolutionary theory assumes that this adaptation is more difficult when environmental conditions change rapidly. Sequential antibiotic therapy, which involves switching between different antibiotics in a short time, could therefore lead to a reduction in the spread of resistance. This therapeutic approach is usually not considered in medical treatment and is also hardly investigated in basic research—despite the possible long-term benefits.