Recently, a research group led by Prof. Yang Liangbao from the Hefei Institutes of Physical Science (HFIPS) of the Chinese Academy of Sciences (CAS) developed in-situ Surface-enhanced Raman spectroscopy (SERS) readout strategy to improve the reliability of beta-galactosidase activity assay based on X-gal staining. Relevant research results have been published in Talanta.