Noninvasive, label-free optical method visualizes deep, cellular brain disease in vivo
Using long wavelength near-infrared light, scientists at UC Davis developed a label-free microscopy approach that achieves a unique combination of deep, high resolution, and minimally invasive brain imaging. The technique images neurons and axonal myelination across the mouse neocortex and some sub-cortical regions, through the thinned skull. Now studies of brain disease can be conducted deep in the mouse brain through a minimally invasive and simple surgical preparation.