Vaccine manufacturing made enormous strides in 2020, but the complexity of SARS-CoV-2 vaccines has highlighted the value of inoculations that can be made cheaply and transported and stored without refrigeration. A new needle-free cholera vaccine has been made by grinding up genetically modified grains of rice and can be stored long-term at room temperature. This innovation has shown no obvious side effects and a good immune response in its Phase 1 clinical trial.