In a study published in Nature Methods, a team led by Prof. Xiong Wei and Prof. CANG Chunlei from University of Science and Technology of China of the Chinese Academy of Sciences realized lysosome typing for the first time based on single lysosome metabonomic information by establishing a single lysosome metabonomic mass spectrometry detection technology, and explored the heterogeneity changes of lysosome metabonomics in the process of cellular senescence.