Beekeepers across the United States lost 45.5% of their managed honey bee colonies from April 2020 to April 2021, according to preliminary results of the 15th annual nationwide survey conducted by the nonprofit Bee Informed Partnership (BIP). These losses mark the second highest loss rate the survey has recorded since it began in 2006 (6.1 percentage points higher than the average annual loss rate of 39.4%). The survey results highlight the continuing high rates of honey bee colony turnover. The high loss rate was driven by both elevated summer and winter losses this year, with no clear progression toward improvement for beekeepers and their colonies. BIP hopes to use the survey results to better understand how colony losses are experienced by beekeepers, and what can be done to reduce losses in future seasons.