As the country gets vaccinated and begins to reopen, testing remains a key element of safe interactions. Rapid testing for COVID-19 has become more common and accessible, including over-the-counter (OTC) tests approved by the U.S. Food and Drug Administration (FDA). Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society, puts five of these at-home rapid tests through their paces to gauge efficacy and ease of use in a new cover story.