Israeli airstrikes on Gaza City flattened three buildings and killed at least 42 people Sunday, Palestinian medics said. Despite the heavy death toll and international efforts to broker a cease-fire, Israeli Prime Minister Benjamin Netanyahu signaled the fourth war with Gaza’s Hamas rulers would rage on. In a televised address, Netanyahu said Sunday evening the attacks were continuing at “full-force” and will “take time.“ Israel “wants to levy a heavy price” from the Hamas militant group, he said, flanked by his defense minister and political rival, Benny Gantz, in a show of unity. The Israeli air assault early Sunday was the deadliest single attack since heavy fighting broke out between Israel and Hamas nearly a week ago, marking the worst fighting here since their devastating 2014 war in Gaza. The airstrikes hit a major downtown street of residential buildings and storefronts over the course of five minutes after midnight, destroying two adjacent buildings and one about 50 yards (meters) down the road. At one point, a rescuer shouted, “Can you hear me?” into a hole in the rubble. “Are you OK?” Minutes later, first responders pulled a survivor out and carried him off on an orange stretcher. The Gaza Health Ministry said 16 women and 10 children were among those killed, with more than 50 people wounded, and rescue efforts are still underway. Earlier, the Israeli military said it destroyed the home of Gaza’s top Hamas leader, Yahiyeh Sinwar, in a separate strike in the southern town of Khan Younis. It was the third such attack in the last two days on the homes of senior Hamas leaders, who have gone underground. Israel appears to have stepped up strikes in recent days to inflict as much damage as possible on Hamas as international mediators work to end the fighting and stave off an Israeli ground invasion in Gaza. But targeting the group’s leaders could hinder those efforts. A U.S. diplomat is in the region to try to de-escalate tensions, and the U.N. Security Council is meeting Sunday. In its airstrikes, Israel has leveled a number of Gaza City’s tallest office and residential buildings, alleging they contain Hamas military infrastructure. Among them was the building housing The Associated Press office and those of other media outlets. The latest outbreak of violence began in east Jerusalem last month, when Palestinian protests and clashes with police broke out in response to Israeli police tactics during Ramadan and the threatened eviction of dozens of Palestinian families by Jewish settlers. A focal point of clashes was the Al-Aqsa Mosque, a frequent flashpoint that is located on a hilltop compound that is revered by both Muslims and Jews. Hamas fired rockets toward Jerusalem late Monday, triggering the Israeli assault on impoverished Gaza, which is home to more than 2 million Palestinians and has been under an Israeli and Egyptian blockade since Hamas seized power from rival Palestinian forces in 2007. At least 188 Palestinians have been killed in Gaza, including 55 children and 33 women, with 1,230 people wounded. Eight people in Israel have been killed, including a 5-year-old boy and a soldier. Speaking alongside Netanyahu on Sunday, Israel’s military chief, Lt. Gen. Aviv Kohavi, said Hamas did not anticipate Israel’s overwhelming response to its rocket fire. “Hamas made a serious and grave mistake and didn’t read us properly.” The turmoil has also spilled over elsewhere, fueling protests in the occupied West Bank and stoking violence within Israel between its Jewish and Arab citizens, with clashes and vigilante attacks on people and property. On Sunday, a driver rammed into an Israeli checkpoint in the east Jerusalem neighborhood of Sheikh Jarrah — where the Palestinian families had been threatened with eviction — injuring six officers before police shot and killed the attacker, Israeli police said. The violence also sparked pro-Palestinian protests in cities across Europe and the United States, with French police firing tear gas and water cannons at demonstrators in Paris. Subscribe to our YouTube channel: https://bit.ly/2TwO8Gm Bloomberg Quicktake brings you live global news and original shows spanning business, technology, politics and culture. Make sense of the stories changing your business and your world. To watch complete coverage on Bloomberg Quicktake 24/7, visit http://www.bloomberg.com/qt/live, or watch on Apple TV, Roku, Samsung Smart TV, Fire TV and Android TV on the Bloomberg app. Have a story to tell? Fill out this survey for a chance to have it featured on Bloomberg Quicktake: https://cor.us/surveys/27AF30 Connect with us on… YouTube: https://www.youtube.com/user/Bloomberg Breaking News on YouTube: https://www.youtube.com/c/BloombergQuickTakeNews Twitter: https://twitter.com/quicktake Facebook: https://www.facebook.com/quicktake Instagram: https://www.instagram.com/quicktake