Hematopoietic stem/progenitor cells (HSPCs) include hematopoietic stem cells and several lineage-biased hematopoietic progenitor cells, which can provide all blood cell types in an adult organism. Among them, hematopoietic stem cells have the ability of self-renewal and multi-lineage differentiation, and can rapidly respond under acute hematopoietic conditions. Meanwhile, the hematopoietic progenitor cells can maintain the supply of blood cells in homeostatic hematopoiesis. In a word, HSPCs are the core of the blood system, once their homeostasis is destroyed, it will lead to serious blood diseases and even death. Therefore, the researches associated with the HSPCs can provide a strong support for relevant theoretical studies and clinical treatments.