Iran said the U.S. must first return to the 2015 nuclear deal and lift sanctions if it wants talks with the Islamic Republic, appearing to snub an effort by the Biden administration to begin direct discussions before officially rejoining the accord. Supreme Leader Ayatollah Ali Khamenei called it Iran’s “final policy” on the matter in an Instagram post, reiterating a statement he made this week. Earlier Foreign Ministry spokesman Saeed Khatibzadeh said the “key sequence” for engagements between the two nations was commitment, action and then a meeting. The reaction highlighted the challenges in ending an impasse that has threatened to tip the Persian Gulf region into a new conflict in the years since former President Donald Trump exited the international agreement and reimposed sanctions. Iran is set next week to restrict snap international inspections of its nuclear sites, a significant hardening of its stance in the face of punishing U.S. penalties that threatens to make concessions by either side more difficult. On Thursday, the Biden administration said it would be willing to meet with Iran to discuss a “diplomatic way forward” in efforts to return to the nuclear deal, a first step toward easing tensions. “The United States would accept an invitation from the European Union High Representative to attend a meeting of the P5+1 and Iran to discuss a diplomatic way forward on Iran’s nuclear program,” State Department spokesman Ned Price said in a statement. The P5+1 refers to the participants in the nuclear deal with Iran: China, Russia, France, the U.K., the U.S and Germany. Biden also lifted travel restrictions on Iranian envoys and reversed a Trump-era claim that the U.S. had reimposed -- or “snapped back” -- United Nations sanctions on Iran, according to a letter sent to the UN Security Council and seen by Bloomberg. The offer is a politically risky effort by President Joe Biden to move beyond the standoff after the slew of U.S. sanctions cratered Iran’s economy and infuriated other world leaders, who argued that the accord and the inspections regime it created had reined in Tehran’s nuclear program. The U.S. moves were a “positive step” but not enough to persuade Iran to reverse changes to its nuclear program or keep the wider inspections regime, said Diako Hosseini, an analyst at the Tehran-based Center for Strategic Studies, a government-run research institute that advises the president. “It’s a weak beginning to a real diplomatic effort,” Hosseini said, while adding it could still create the room needed for progress. European parties to the nuclear deal welcomed the U.S. overture. Germany urged Iran “not to implement and to rethink these announced limits on IAEA inspectors,” Steffen Seibert, spokesman for Chancellor Angela Merkel, said at a press conference in Berlin. However both Russia and China supported Iran’s stance, stressing that Washington’s official return to the nuclear deal remains key to ending the stalemate. While a turn away from a policy of sanctions is “by itself” a good thing, “it is the restoration of the JCPOA regime that is important,” Kremlin spokesman Dmitry Peskov told reporters on a conference call on Friday, using a formal abbreviation for the accord, officially known as the Joint Comprehensive Plan of Action. China’s Foreign Ministry spokeswoman Hua Chunying told reporters on Thursday that the U.S. rejoining the deal was the “only correct approach to resolve the impasse” and called for its “unconditional return as soon as possible.” The U.S. offer to hold talks was aimed at restoring a diplomatic pathway with Iran, which has been gradually abandoning its commitments under the nuclear deal in response to the Trump administration’s “maximum pressure” sanctions campaign. U.S. and European officials are particularly alarmed by Iran’s decision to stop letting the International Atomic Energy Agency conduct snap inspections by suspending the so-called Additional Protocol from Feb. 23. The Director General of the agency, Rafael Mariano Grossi, is due to arrive in Tehran on Saturday for talks with Iranian officials about nuclear inspections. Subscribe to our YouTube channel: https://bit.ly/2TwO8Gm Bloomberg Quicktake brings you live global news and original shows spanning business, technology, politics and culture. Make sense of the stories changing your business and your world. To watch complete coverage on Bloomberg Quicktake 24/7, visit http://www.bloomberg.com/qt/live, or watch on Apple TV, Roku, Samsung Smart TV, Fire TV and Android TV on the Bloomberg app. Have a story to tell? Fill out this survey for a chance to have it featured on Bloomberg Quicktake: https://cor.us/surveys/27AF30 Connect with us on… YouTube: https://www.youtube.com/user/Bloomberg Breaking News on YouTube: https://www.youtube.com/c/BloombergQuickTakeNews Twitter: https://twitter.com/quicktake Facebook: https://www.facebook.com/quicktake Instagram: https://www.instagram.com/quicktake