Surprising behavior of transcription factors challenges theories of gene regulation
Published Date: 1/27/2021
Source: phys.org
How cells develop and the diseases that arise when development goes wrong have been a decades-long research focus in the laboratory of Distinguished Professor of Biology Ellen Rothenberg. In particular, the lab studies the development of immune cells known as T cells, which act as "intelligence agents"—they circulate throughout the body, detect threats, and determine what kind of response the immune system should make. However, when the many stages of T cell development do not occur perfectly, leukemia occurs.