Liquid droplets have recently gained renewed attention as a simplified model for a variety of fascinating physical phenomena at the scale of the cell nucleus to stellar black holes. In a new report now published in Science Advances, Yuyang Gu and a team of scientists in the U.S. presented an acoustofluidic centrifugation technique that used the entanglement of acoustic wave actuation and the spin of a fluidic droplet to accomplish nanoparticle enrichment and separation. They combined acoustic scanning and droplet spinning methods to achieve rapid nanoparticle concentrations and size-based separation with a resolution sufficient to identify and isolate exosome sub-populations.