Oligourea foldamers mimic peptides' alpha-helices and effectively bind to drug targets
Published Date: 12/7/2020
Source: phys.org
Some useful drugs consist of peptides acting on their protein targets. To make them more efficient and stable, scientists have found a way to replace crucial segments of the peptides with ureido units. These oligoureas, which are composed of urea-based units, fold into a structure similar to that of peptides. Oligourea-based "fake" peptides enhance the options for rational drug design, concludes the study published in the journal Angewandte Chemie.