Imaging combined with genetic screening of cells enhances genomic discoveries
Published Date: 10/18/2019
Source: phys.org
Scientists routinely use genetic screens to perturb, or change the activity of, genes in mammalian cells, one at a time, to learn what those genes do. Pooled screens take this same approach but typically involve many more genetic perturbations across the whole genome. However, with pooled screens, scientists could only track cell survival and other simple whole-cell measurements.