Since Friedrich Wohler synthesized urea (by accident) back in 1828, chemical synthesis—and organic synthesis for that—has been a driving force in pharmaceutical innovation. Improving the lives of people worldwide, the medicines available nowadays are only possible thanks to the continuous advancement of synthetic chemistry, allowing scientists to design and build new molecules. Now, Marcos G. Suero and his research group at the Institute of Chemical Research of Catalonia (ICIQ) present a new reaction that allows for the edition of organic molecule's skeletons, opening up new avenues of research.